TCS Industries Limited (China-sourced API supplier) supplies Omeprazole — API CAS 73590-58-6 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Omeprazole |
|---|---|
| Structural Formula |  |
| CAS Number | 73590-58-6 |
| Molecular Formula | C17H19N3O3S |
| Molecular Weight | 345.4 g/mol |
| InChIKey | SUBDBMMJDZJVOS-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from light and moisture |
Omeprazole (CAS 73590-58-6) is a proton pump inhibitor (PPI) with the formula C₁₇H₁₉N₃O₃S (MW 345.42). It irreversibly inhibits the gastric H⁺/K⁺-ATPase (proton pump) in parietal cells, reducing gastric acid secretion by up to 99%. Omeprazole is used for gastroesophageal reflux disease (GERD), peptic ulcer, and H. pylori eradication, and is on the WHO Model List of Essential Medicines.
Omeprazole is monographed in USP, BP, Ph.Eur. and JP. It is acid-labile and light-sensitive, which drives the requirement for enteric-coated pellet or tablet formulations and light-protective packaging throughout the supply chain. TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Omeprazole API in development and commercial quantities for oral solid dosage and compounding programs.
> Applications
Enteric-coated oral solid dosage forms
Most omeprazole finished products use enteric-coated pellets filled into hard gelatin capsules, or enteric-coated tablets. The API is blended with an alkaline stabilizer (often magnesium hydroxide or sodium phosphate), pelletized, then coated with a pH-dependent polymer such as Eudragit L30D-55 or hypromellose phthalate to prevent acid degradation in the stomach. Particle size distribution and polymorphic form of the incoming API affect pellet uniformity and coating efficiency. Sachs et al. (Annu Rev Pharmacol Toxicol, 1995, 35:277–305) established the covalent binding mechanism of omeprazole to the proton pump, which remains the pharmacological basis for all PPI enteric-coating design.
Compounding and hospital pharmacy preparations
Omeprazole simplified suspension (also known as omeprazole–sodium bicarbonate suspension) is prepared in compounding pharmacies for nasogastric tube administration. The API is dissolved in 8.4% sodium bicarbonate solution, which provides both alkaline stability and buffering in the stomach. Compounding-grade omeprazole follows the same CAS and pharmacopoeial identity but may have different particle-size or flowability requirements than production-grade material.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Omeprazole with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and development quantities: 100 g to 5 kg packs for formulation trials, analytical method validation, and vendor qualification. Light-protective packaging is standard.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances (omeprazole sulfone, 5-methoxy-2-mercaptobenzimidazole), enantiomeric ratio (racemic for omeprazole; S-enantiomer for esomeprazole), loss on drying, residual solvents, heavy metals, and microbial limits. White to off-white powder. Slightly soluble in water, soluble in methanol. Sensitive to acid, light, and moisture. Meets USP (Omeprazole), Ph.Eur. (Omeprazolum), and BP. COA and MSDS are standard.
> Packaging
Omeprazole is light-sensitive and moisture-sensitive. Packaging options include amber glass bottles for small quantities, aluminium-foil-lined bags or double PE-lined fibre drums for commercial lots (typically 25 kg), and palletized export packaging with desiccant. All containers are sealed under inert atmosphere where specification requires it. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Omeprazole is monographed in USP, Ph.Eur. (Omeprazolum), BP, and JP. FDA-approved in 1989 (Prilosec, now OTC). EMA-authorized. On the WHO Model List of Essential Medicines. Off-patent with extensive generic availability. Available OTC in many markets. Esomeprazole (S-enantiomer, Nexium) has separate approvals. DMF support available.
> Alias Index
- INN: Omeprazole
- CAS Number: 73590-58-6 (free base); 95382-33-5 (magnesium salt)
- Formula: C₁₇H₁₉N₃O₃S (MW 345.42)
- Brand names: Prilosec (OTC), Losec
- ATC code: A02BC01
- Related: Esomeprazole (S-enantiomer, Nexium)
- Commercial request terms: omeprazole API, Prilosec generic, PPI API, proton pump inhibitor, omeprazole magnesium, TCS Industries Limited
> FAQ
What pharmacopoeial grades of Omeprazole are available?
TCS can source Omeprazole to USP, BP, Ph.Eur. or JP specifications. The applicable pharmacopoeial grade, assay requirement and impurity limits should be confirmed at inquiry stage so that the correct source and COA format can be matched.
What documents are available for Omeprazole orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Omeprazole to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Does Omeprazole require special storage and packaging?
Yes. Omeprazole is light-sensitive and moisture-sensitive. It should be stored at controlled room temperature, protected from light, in sealed containers. Commercial packaging uses aluminium-foil-lined bags or amber containers with desiccant. TCS provides light-protective packaging as standard for all Omeprazole shipments.
Is polymorphic form specified for Omeprazole API?
Yes. Omeprazole exists in multiple polymorphic forms. The crystalline form affects dissolution behavior and stability. Buyers typically specify the required form at inquiry stage. Polymorphic form is confirmed by XRPD and reported on the COA.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Omeprazole packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the difference between Omeprazole and Esomeprazole?
Omeprazole (CAS 73590-58-6) is a racemic mixture of S- and R-enantiomers. Esomeprazole (CAS 119141-88-7) is the pure S-enantiomer, marketed as Nexium. They are different CAS numbers and different regulatory entries. Specify which compound is required when requesting a quotation.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.