Procarbazine Hydrochloride: Methylhydrazine Antineoplastic Agent
Procarbazine is a methylhydrazine derivative that requires metabolic activation to generate alkylating species and free radicals that damage DNA. It inhibits DNA, RNA, and protein synthesis through multiple mechanisms including methylation of nucleic acids and inhibition of transmethylation reactions. Procarbazine also has weak monoamine oxidase (MAO) inhibitory activity.
Product Profile
| CAS Number | 366-70-1 |
|---|---|
| Molecular Formula | C12H19N3O · HCl |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Antineoplastic |
| Storage | Store at controlled room temperature, protect from light and moisture |
Applications
Procarbazine HCl is administered orally, primarily as a component of the MOPP regimen (mechlorethamine, vincristine, procarbazine, prednisone) for Hodgkin’s lymphoma, and the PCV regimen (procarbazine, lomustine, vincristine) for brain tumors including anaplastic oligodendroglioma and glioblastoma. Its ability to cross the blood-brain barrier makes it valuable in CNS malignancies. Due to its MAO inhibitory activity, patients must avoid tyramine-rich foods and sympathomimetic drugs during treatment. Procarbazine is also mutagenic and carcinogenic, with secondary malignancies (particularly acute leukemia) being a long-term risk of therapy.
Why Source from TCS
TCS supplies procarbazine hydrochloride to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Procarbazine HCl 366-70-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Procarbazine HCl 366-70-1 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Procarbazine HCl 366-70-1?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.