TCS Industries Limited (China-sourced API supplier) supplies Framycetin Sulphate — API CAS 4146-30-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Framycetin Sulphate |
|---|---|
| Structural Formula |  |
| CAS Number | 4146-30-9 |
| Molecular Formula | C23H52N6O25S3 |
| Molecular Weight | 908.9 g/mol |
| InChIKey | KWBUARAINLGYMG-JGMIRXPNSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to yellowish-white hygroscopic powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature, protect from moisture |
Framycetin Sulphate (CAS 4146-30-9) is the sulfate salt of framycetin (also known as neomycin B), an aminoglycoside antibiotic. It has the formula C₂₃H₄₆N₆O₁₃·xH₂SO₄ (free base MW 614.64). Framycetin is used topically for skin infections, ocular infections, and as a component of ENT and dermatological preparations. It is not used systemically due to nephrotoxicity and ototoxicity.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Framycetin Sulphate API in pharmaceutical grade for global procurement programs.
> Applications
Topical antibiotic for skin and eye infections
Framycetin sulfate 0.5–1.0% cream or ointment is used for superficial bacterial skin infections, burns, and wound infections caused by susceptible organisms (S. aureus, E. coli, Proteus, Klebsiella). Ophthalmic preparations (0.5% drops/ointment, Soframycin) are used for bacterial conjunctivitis and blepharitis. Assalian et al. (Can J Ophthalmol, 1999, 34:389–394) evaluated the clinical efficacy and safety of framycetin-based ophthalmic preparations in bacterial ocular infections.
ENT and nasal formulations
Framycetin is used in combination nasal sprays and ear drops with dexamethasone and gramicidin (Sofradex) for otitis externa and allergic rhinitis with secondary infection. Its poor systemic absorption from topical application provides a safety advantage for surface infections.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Framycetin Sulphate with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for analytical qualification; 1 kg and 5 kg for production. Fermentation-derived pharmaceutical-grade powder. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥90.0% framycetin equivalents), related substances (neomycin A, neomycin C), sulfate content, pH, loss on drying, heavy metals, residual solvents, and microbial limits. White to yellowish powder. Freely soluble in water. Hygroscopic. Identity by HPLC, TLC, and IR. Meets Ph.Eur. (Neomycini sulfas), BP (Framycetin Sulphate), and JP. COA and MSDS are standard.
> Packaging
Framycetin sulfate is a white to yellowish hygroscopic powder. Standard packaging includes double PE-lined foil bags in fibre drums (500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Framycetin sulfate is monographed in BP (Framycetin Sulphate) and Ph.Eur. (as Neomycin sulfate — framycetin is neomycin B). Listed in multiple national formularies for topical use. Not FDA-approved as a separate entity (neomycin sulfate USP is used in the US market). Generic topical framycetin products available globally. DMF support available.
> Alias Index
- INN: Framycetin
- CAS Number: 4146-30-9 (sulfate)
- Chemical identity: Neomycin B sulfate
- Formula: C₂₃H₄₆N₆O₁₃ (free base MW 614.64)
- Brand names: Soframycin, Sofradex (combination)
- ATC code: D06AX04 (topical), S01AA07 (ophthalmic)
- Commercial request terms: framycetin sulphate API, neomycin B sulfate, Soframycin generic, topical aminoglycoside, TCS Industries Limited
> FAQ
Is Framycetin the same as Neomycin?
Framycetin is neomycin B, the major active component of the neomycin complex. Commercial neomycin sulfate (USP/Ph.Eur.) is a mixture of neomycin B (≥90%) and neomycin C. Framycetin sulfate (BP) specifically designates the purified neomycin B component. They are therapeutically equivalent for topical use.
What documents are available for Framycetin Sulphate orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Framycetin Sulphate to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why is Framycetin only used topically?
Framycetin (neomycin B) causes nephrotoxicity and irreversible ototoxicity when absorbed systemically. Oral bioavailability is minimal (<3%). Topical application provides effective local antibiotic concentrations without significant systemic absorption. Systemic use has been abandoned in favor of less toxic aminoglycosides (gentamicin, tobramycin, amikacin).
What is Sofradex?
Sofradex is a combination product containing framycetin sulfate 0.5%, gramicidin 0.005%, and dexamethasone 0.05%. It is used for otitis externa (ear drops) and anterior eye inflammation with infection (eye drops). The combination provides antibiotic coverage with anti-inflammatory action.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Framycetin Sulphate packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources framycetin sulfate from manufacturers who maintain active regulatory files. Fermentation-derived material meeting BP/Ph.Eur. specifications. COA, stability data, and regulatory documentation are provided for generic topical formulation development.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.