TCS Industries Limited (China-sourced API supplier) supplies Doramectin CAS 117704-25-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Doramectin |
|---|---|
| Structural Formula |  |
| CAS Number | 117704-25-3 |
| Molecular Formula | C50H74O14 |
| Molecular Weight | 899.1 g/mol |
| InChIKey | QLFZZSKTJWDQOS-YDBLARSUSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to yellowish powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature, protect from light |
Doramectin (CAS 117704-25-3) is a macrocyclic lactone (avermectin) antiparasitic with the formula C₅₀H₇₄O₁₄ (MW 899.11). It is produced by a mutant strain of Streptomyces avermitilis using cyclohexanecarboxylic acid as a biosynthetic precursor. Doramectin potentiates glutamate-gated chloride channels in nematodes and arthropods. It is used in cattle, swine, and horses for endo- and ectoparasite control.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Doramectin API for veterinary injectable and pour-on formulation programs.
> Applications
Injectable formulations for cattle and swine
Doramectin is formulated as a 1% w/v injectable solution (e.g., Dectomax, Zoetis) administered subcutaneously in cattle at 200 µg/kg and intramuscularly in swine at 300 µg/kg. The API is dissolved in sesame oil and ethyl oleate for sustained release and depot effect. Injection site residue management is critical for meat-producing animals — the withdrawal period is typically 35 days in cattle. Goudie et al. (Vet Parasitol, 1993, 49:5–15) reviewed the pharmacology and spectrum of doramectin across livestock species.
Pour-on formulations for cattle
Doramectin pour-on solution (5 mg/mL) is applied topically along the dorsal midline at 500 µg/kg for control of external and internal parasites simultaneously. Pour-on formulations require penetration enhancers and evaporation-resistant vehicles for consistent transdermal absorption. Rain fastness and hair coat condition affect efficacy.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Doramectin with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Development and qualification quantities: 100 g to 5 kg packs for formulation trials, stability studies, and veterinary drug registration submissions.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥95.0%), related substances (B1b avermectin components), specific optical rotation, loss on drying, heavy metals, residual solvents, and microbial limits. White to yellowish crystalline powder. Practically insoluble in water, soluble in chloroform and acetone. Identity by HPLC and UV. Meets in-house veterinary pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Doramectin is a white to yellowish crystalline powder. Standard packaging includes sealed foil bags under nitrogen in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Doramectin is approved for veterinary use only (Dectomax, Zoetis). FDA-CVM approved for cattle and swine. Not approved for dairy cattle of breeding age. Withdrawal periods apply for meat (cattle: 35 days SC, swine: 24 days IM). Not approved for companion animals or human use. Regulatory documentation available.
> Alias Index
- Chemical name: Doramectin (25-cyclohexyl avermectin B1a)
- CAS Number: 117704-25-3
- Formula: C₅₀H₇₄O₁₄ (MW 899.11)
- Brand name: Dectomax (Zoetis)
- ATCvet code: QP54AA03
- Related: Ivermectin, Abamectin (other avermectins)
- Commercial request terms: doramectin API, Dectomax generic, avermectin API, cattle antiparasitic, TCS Industries Limited
> FAQ
What formulation types are made from Doramectin API?
Doramectin is formulated as 1% injectable solution and 5 mg/mL pour-on solution. The injectable uses sesame oil/ethyl oleate vehicle for subcutaneous administration in cattle and intramuscular use in swine. Pour-on is applied topically in cattle. API solubility and stability should be confirmed for the target vehicle.
What documents are available for Doramectin orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Doramectin supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
What withdrawal periods apply to Doramectin in food-producing animals?
Withdrawal periods are market-specific. Typical values: cattle (meat) 35 days for injectable, swine (meat) 24 days. Pour-on formulations may differ. Buyers must confirm the applicable withdrawal period per their local regulatory authority before formulating.
Is Doramectin effective against external parasites?
Yes. Doramectin is an endectocide — active against both internal parasites (gastrointestinal nematodes, lungworms) and external parasites (lice, mange mites, ticks, grubs). This broad-spectrum profile makes injectable doramectin a single-treatment solution for mixed parasite burdens in cattle.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Doramectin packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
How does Doramectin differ from Ivermectin?
Both are avermectins. Doramectin (CAS 117704-25-3) has a cyclohexyl group at C-25 instead of the sec-butyl group in ivermectin (CAS 70288-86-7). This structural difference gives doramectin longer plasma half-life and higher lipophilicity, resulting in extended parasite protection per single dose. Specify which avermectin is required at inquiry.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.