Framycetin sulphate (CAS 4146-30-9) is the sulfate salt of framycetin (neomycin B), an aminoglycoside antibiotic produced by Streptomyces lavendulae. Aminoglycosides exert their antibacterial effect by binding to the 30S ribosomal subunit and disrupting protein synthesis, leading to misreading of mRNA and bactericidal activity against a range of Gram-negative and some Gram-positive bacteria.
Framycetin Sulphate 4146-30-9 from TCS INDUSTRIES LIMITED is offered as a high-purity topical and local-use antibacterial API. It is commonly used in dermatological creams and ointments, otic (ear) preparations and ophthalmic combinations, often in conjunction with anti-inflammatory agents to treat infected dermatoses, otitis externa and surface eye infections.
Because systemic aminoglycoside exposure is associated with nephrotoxicity and ototoxicity, framycetin sulphate is generally reserved for topical or local administration, where systemic absorption is limited, and use is carefully managed.
Within TCS GROUP’s
Active Pharmaceutical Ingredient
portfolio, framycetin sulphate complements other anti-infective APIs, including:
- Clarithromycin 81103-11-9 – a macrolide antibiotic frequently used in respiratory and Helicobacter pylori indications.
- Daptomycin 103060-53-3 – a lipopeptide antibiotic for severe Gram-positive infections, highlighting the company’s expertise in hospital-use anti-infectives.
Topical formulations containing framycetin sulphate must carefully balance antibacterial efficacy, skin or mucosal tolerability and resistance stewardship. Excipient choice—from emulsifying waxes and fatty alcohols to viscosity modifiers—plays a major role in achieving good spreadability, stability and patient acceptance. TCS INDUSTRIES LIMITED also supplies a variety of suitable Pharmaceutical Excipients to complete these formulations.
By working with Framycetin Sulphate 4146-30-9 from TCS GROUP, manufacturers can develop reliable, high-quality topical and local anti-infective products supported by a strong anti-infective API platform and comprehensive technical documentation.