Diphemanil methylsulfate (CAS 62-97-5) is a quaternary ammonium anticholinergic agent that acts by binding muscarinic acetylcholine receptors (mAChRs) and reducing secretory activity in the gastrointestinal tract and exocrine glands. Clinically, it has been used to decrease stomach acid, saliva and sweat secretion, and has topical applications in the management of hyperhidrosis.
On the TCS website,
Diphemanil Methylsulfate Ingredients 62-97-5
is presented as a pharmaceutical ingredient for use in solid and liquid dosage forms, including oral preparations and topical formulations where anticholinergic effects are desired. Its quaternary ammonium structure limits penetration across the blood–brain barrier compared with tertiary amines, contributing to a more peripheral pharmacological profile.
As an API and functional ingredient, Diphemanil Methylsulfate sits within the TCS
Active Pharmaceutical Ingredient
portfolio, alongside a variety of cardiovascular, ophthalmic and anti-infective APIs. In the context of autonomic-modulating compounds, it is conceptually related to:
- Demetronium Bromide 56-94-0 – another cholinesterase/parasympathomimetic ophthalmic agent used historically in glaucoma, which also interacts with cholinergic pathways.
- Cyclosporin A 59865-13-3 – while mechanistically different (immunosuppressant peptide), it shares a role in specialised, high-value therapeutic areas requiring careful monitoring and strong regulatory support.
For oral solid dosage forms, Diphemanil Methylsulfate can be formulated as tablets or capsules using a suitable excipient base. TCS INDUSTRIES LIMITED provides compatible options within its
offering—such as mineral fillers and advanced superdisintegrants—to help achieve robust tablet performance and reproducible release.
Because anticholinergic agents can influence multiple body systems, formulation must ensure dose precision and consistent bioavailability, while manufacturing must handle the material with appropriate controls to avoid dust exposure. With TCS GROUP’s emphasis on quality, documentation and technical support, pharmaceutical companies can integrate Diphemanil Methylsulfate 62-97-5 confidently into their gastrointestinal, autonomic or topical hyperhidrosis product pipelines.