Chlorambucil (CAS 305-03-3) is a bifunctional alkylating agent used as an oral chemotherapy drug, historically important in the treatment of chronic lymphocytic leukemia (CLL), Hodgkin lymphoma and non-Hodgkin lymphoma. It belongs to the nitrogen mustard class and exerts its antitumor effect by forming covalent bonds with DNA, leading to crosslinking, interference with replication and transcription, and ultimately apoptosis of malignant cells.
At TCS INDUSTRIES LIMITED, Chlorambucil 305-03-3 | Alkylating Agent Oncology API Manufacturer China is supplied as a high-purity Active Pharmaceutical Ingredient (API) suitable for oral solid dosage forms. The material is supported by detailed quality documentation, including impurity profiles and regulatory-oriented data, to assist partners in dossier preparation and global submissions. Chlorambucil is typically formulated into film-coated tablets to protect the active from moisture and light and to facilitate safe handling.
Because chlorambucil is cell-cycle-nonspecific and cytotoxic, careful dose individualisation and monitoring are essential. Manufacturers working with this API must ensure appropriate containment, worker protection and waste management. Stability studies and protective packaging strategies are also critical, given the sensitivity of nitrogen mustards to hydrolysis and environmental conditions.
TCS GROUP positions chlorambucil within a broader oncology and hospital-care API portfolio. For combination protocols or sequential therapies, developers may also work with other cytotoxic agents from the same supplier, such as Carmustine 154-93-8 | Oncology Chemotherapy API Manufacturer China, to simplify supplier qualification and batch evaluation. In infectious-disease-compromised patients, antiviral coverage can be relevant; in this context, Cidofovir 113852-37-2 | Antiviral Nucleotide Analog API Supplier China provides an additional option to support CMV retinitis management under expert clinical supervision.
A high-level overview of the company’s oncology and chronic-care portfolio can be found under the Active Pharmaceutical Ingredient category, where chlorambucil is listed alongside cardiovascular, anti-infective and specialty APIs. Working with TCS INDUSTRIES LIMITED allows manufacturers to benefit from integrated technical support, consistent quality and secure supply, helping bring reliable oncology products to markets that depend on them.