Pregelatinized Starch: Combined Binder and Disintegrant for Direct Compression
Pregelatinized starch is a physically modified starch (typically maize-derived) that has been processed to rupture the starch granules, making it cold-water soluble. This dual functionality — binding when dry-compressed and disintegrating upon contact with aqueous media — makes it one of the few excipients that can serve as both binder and disintegrant in the same tablet formulation. It is particularly valued in direct compression processes where simplicity is paramount.
Product Profile
| CAS Number | 9005-25-8 |
|---|---|
| Appearance | White to off-white, moderately fine powder |
| Function | Binder / disintegrant / filler |
| Typical Use Level | 5–20% as binder-disintegrant in direct compression |
| Compendial Grade | EP / USP-NF |
Formulation Applications
Pregelatinized starch is used in direct compression tablet formulations where it simultaneously binds the powder blend during compaction and promotes rapid disintegration upon hydration. At concentrations of 5–10%, it primarily acts as a binder; at higher levels (15–20%), its disintegrant properties become more pronounced. It flows better than native starch and compresses without the need for granulation, streamlining manufacturing. In capsule fills, it improves powder flow and content uniformity. It can also serve as a thickening and gelling agent in topical and oral liquid preparations.
Why Source from TCS
TCS supplies Pregelatinized Starch in pharmaceutical grade to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Pregelatinized Starch -68412-29-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Pregelatinized Starch -68412-29-3 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Pregelatinized Starch -68412-29-3?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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