TCS Industries Limited (China-sourced API supplier) supplies Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder CAS 9004-64-2 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder |
|---|---|
| Structural Formula |  |
| CAS Number | 9004-64-2 |
| Molecular Formula | Hydroxypropyl cellulose polymer |
| Molecular Weight | Grade-dependent (typ. 100,000 g/mol) |
| InChIKey | Not applicable (polydisperse polymer) |
| SMILES | Available on request where applicable |
| Appearance | White to yellowish-white powder or granules |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Low-Substituted Hydroxypropyl Cellulose (CAS 9004-64-2, L-HPC) is a non-ionic cellulose ether with a hydroxypropoxyl content of 5.0–16.0% (lower than HPC, which has 53–77%). L-HPC is water-insoluble due to its low substitution level and functions as a tablet disintegrant and binder in pharmaceutical formulations. It swells in water without dissolving, generating disintegration force within the tablet matrix.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Low-Substituted HPC in pharmaceutical grade (NF/JP) for global procurement programs.
> Applications
Tablet disintegrant and binder
L-HPC serves a dual function: as a disintegrant (swelling in water to break apart tablets) and as a dry binder (improving tablet hardness). Typical use level is 5–15% in tablet formulations. L-HPC produces rapid disintegration without the gel formation that can retard drug dissolution. It is particularly effective in orally disintegrating tablets (ODTs). Yassin et al. (Drug Dev Ind Pharm, 2015, 41:239–247) evaluated L-HPC as a multifunctional excipient combining binding and disintegration in direct compression ODT formulations.
Granulation aid
L-HPC is used as a wet granulation binder (dispersed or dissolved in granulation fluid) and as a dry addition disintegrant. Its dual functionality can simplify formulations by replacing separate binder and disintegrant excipients. Different particle size grades (LH-11, LH-21, LH-31 equivalents) are optimized for different functions.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples for formulation trials; 20 kg bags for production. Multiple particle size grades (LH-11, LH-21, LH-31 equivalents) available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include hydroxypropoxyl content (5.0–16.0%), particle size distribution (grade-specific: LH-11 ~50 µm, LH-21 ~150 µm, LH-31 ~200 µm), loss on drying (≤5.0%), residue on ignition (≤0.3%), pH (5.0–7.5), heavy metals (Pb ≤10 ppm), settling volume, and microbial limits. White to yellowish-white powder or granular. Meets NF and JP monographs. COA and MSDS are standard.
> Packaging
L-HPC is a white to yellowish-white powder, slightly hygroscopic. Standard packaging includes 20 kg multiply paper bags with PE liner, palletized. Store at room temperature in dry conditions (≤65% RH). Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
L-HPC is monographed in NF (Low-Substituted Hydroxypropyl Cellulose) and JP (Hydroxypropyl Cellulose, Low-Substituted). Listed in the FDA IID for oral dosage forms. Not a food additive (pharmaceutical excipient only). No special import permits for pharmaceutical-grade material.
> Alias Index
- Chemical class: Low-substituted hydroxypropyl cellulose ether
- CAS Number: 9004-64-2
- Abbreviation: L-HPC
- Hydroxypropoxyl: 5.0–16.0%
- Pharmacopoeial: NF, JP
- Particle size grades: LH-11 (~50 µm), LH-21 (~150 µm), LH-31 (~200 µm)
- Brand equivalent: L-HPC (Shin-Etsu)
- Commercial request terms: L-HPC NF, low-substituted HPC disintegrant, LH-21 equivalent, ODT excipient, TCS Industries Limited
> FAQ
What is the difference between L-HPC and HPC?
L-HPC (5–16% hydroxypropoxyl) is water-insoluble and used as a disintegrant/binder. HPC (53–77% hydroxypropoxyl) is water-soluble and used as a film coating, binder, and controlled-release polymer. They share the same CAS number but are distinct pharmaceutical excipients with different NF/JP monographs and functional roles.
What documents are available for Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Which L-HPC grade should I use?
LH-11 (fine, ~50 µm): best disintegration performance, used extragranularly. LH-21 (medium, ~150 µm): balanced binding and disintegration, most versatile. LH-31 (coarse, ~200 µm): best binding performance with moderate disintegration. Select based on whether disintegration or binding is the primary requirement.
Is L-HPC suitable for ODTs?
Yes. L-HPC is effective in orally disintegrating tablets (ODTs) at 5–15% due to its rapid swelling without gel formation. It produces fast disintegration (typically <30 seconds) while maintaining sufficient tablet hardness for handling. LH-11 (fine grade) provides the fastest disintegration.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Low-Substituted Hydroxypropyl Cellulose –- Superdisintegrant & Binder packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
How does L-HPC compare to super-disintegrants?
L-HPC (5–15% use level) provides both binding and disintegration. Super-disintegrants (croscarmellose, crospovidone, SSG) at 2–5% provide stronger disintegration but no binding. L-HPC can replace a separate binder + disintegrant in simple formulations, simplifying the excipient list.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.