Low-Substituted Hydroxypropyl Cellulose (L-HPC): Disintegrant and Binder
Low-substituted hydroxypropyl cellulose (L-HPC) is a cellulose derivative with a hydroxypropyl substitution level of 5–16%, which renders it insoluble in water — unlike its fully substituted counterpart HPC. This water-insoluble, swellable character gives L-HPC dual functionality as both a disintegrant and a binder in solid oral dosage forms, a relatively unusual combination among pharmaceutical excipients.
Product Profile
| CAS Number | 9004-64-2 |
|---|---|
| Appearance | White to yellowish-white powder or granules |
| Function | Disintegrant / binder |
| Typical Use Level | 5–20% w/w as disintegrant; 2–5% as binder |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
L-HPC is available in multiple particle size grades (LH-11, LH-21, LH-31, etc.) that influence its disintegration and binding performance. Finer grades provide faster disintegration through swelling, while coarser grades contribute more to binding strength. It is effective in both direct compression and wet granulation processes. Unlike superdisintegrants such as croscarmellose sodium or crospovidone, L-HPC’s disintegration mechanism is based primarily on swelling rather than wicking, and it simultaneously improves tablet hardness — making it particularly useful in formulations where tablet strength and disintegration must be balanced. L-HPC is widely used in Japanese pharmaceutical manufacturing and has gained increasing adoption in European and American formulations.
Why Source from TCS
TCS supplies low-substituted hydroxypropyl cellulose in pharmaceutical grade to formulators across Europe. Multiple particle size grades available with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Low-Substituted Hydroxypropyl Cellulose –9004-64-2?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Low-Substituted Hydroxypropyl Cellulose –9004-64-2 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Low-Substituted Hydroxypropyl Cellulose –9004-64-2?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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