Product name: Low-Substituted Hydroxypropyl Cellulose (L-HPC)
Synonyms: L-HPC
CAS: 9004-64-2 (cellulose derivative)
MF: Modified cellulose polymer
MW: High polymer
Low-substituted hydroxypropyl cellulose is a partially substituted cellulose derivative designed specifically for use in oral solid dosage forms.
It combines strong disintegration capability with binding properties, making it suitable for direct compression, wet granulation, and dry granulation processes.
L-HPC swells rapidly upon contact with aqueous media, promoting fast tablet disintegration and improving dissolution of poorly soluble drugs.
It is particularly useful for high-dose tablets, orally disintegrating tablets, and formulations requiring robust mechanical strength plus rapid breakdown.
Its low substitution level ensures sufficient hydrophilicity while maintaining excellent compressibility and compatibility with a wide range of APIs.
Low-Substituted Hydroxypropyl Cellulose – Superdisintegrant & Binder
