Dimethyl Sulfoxide (DMSO): Polar Aprotic Solvent and Penetration Enhancer
Dimethyl sulfoxide (DMSO) is a highly polar, aprotic solvent with exceptional ability to dissolve both polar and nonpolar compounds. In pharmaceutical applications, it is used as a solvent for drug formulation, a cryoprotectant for cell preservation, and a topical penetration enhancer. It is also an important reaction solvent in chemical synthesis.
Product Profile
| CAS Number | 67-68-5 |
|---|---|
| Molecular Formula | (CH₃)₂SO |
| Appearance | Colourless, hygroscopic liquid with a slight garlic-like odour |
| Function | Solvent / penetration enhancer / cryoprotectant |
| Compendial Grade | EP / USP-NF |
Formulation Applications
DMSO is FDA-approved as the active ingredient in topical formulations for interstitial cystitis (bladder instillation, 50% solution). As a penetration enhancer, it facilitates transdermal delivery of drugs by disrupting the lipid structure of the stratum corneum. In cryopreservation, DMSO at 5–10% concentration protects cells from ice crystal damage during freezing. It is widely used as a process solvent in API synthesis due to its high boiling point (189°C) and ability to dissolve a broad range of organic and inorganic compounds. Formulators should note that DMSO readily penetrates skin and can carry dissolved solutes with it — appropriate handling precautions are essential.
Why Source from TCS
TCS supplies DMSO in pharmaceutical and technical grades to customers across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Dimethyl Sulfoxide (DMSO) –67-68-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Dimethyl Sulfoxide (DMSO) –67-68-5 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Dimethyl Sulfoxide (DMSO) –67-68-5?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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