Doramectin (CAS 117704-25-3) is a macrocyclic lactone antiparasitic antibiotic structurally related to ivermectin and produced as a mutational biosynthetic derivative of avermectins. It is used in veterinary medicine to control a broad spectrum of internal and external parasites—such as gastrointestinal roundworms, lungworms, grubs, lice and mange mites—primarily in cattle and other livestock.
At TCS GROUP,
is offered as a high-quality API intended for injectable, pour-on and other veterinary formulations. Doramectin acts by potentiating glutamate- and GABA-gated chloride channels in nematodes and arthropods, leading to paralysis and death of the parasites while maintaining an acceptable safety margin in treated animals.
As a veterinary antiparasitic, Doramectin belongs to the broader
Active Pharmaceutical Ingredient
category within TCS INDUSTRIES LIMITED, complementing other hospital and serious-infection APIs. For instance:
- Daptomycin 103060-53-3 – a lipopeptide antibiotic for severe Gram-positive infections in human medicine, highlighting the company’s expertise in complex peptide and lipopeptide APIs.
- Cidofovir 113852-37-2 – a nucleotide analog antiviral used for CMV retinitis in immunocompromised patients, another example of advanced anti-infective chemistry in the TCS portfolio.
Doramectin formulations typically require strict control of solvent systems, stabilisers and carriers to ensure accurate dosing and consistent pharmacokinetics in target animals. Long-acting injectable formulations, for example, depend on carefully optimised oil or solvent bases and manufacturing parameters to maintain stability and depot behaviour.
Regulatory expectations around veterinary antiparasitics are stringent, particularly regarding maximum residue limits (MRLs) and withdrawal periods for meat and milk. TCS INDUSTRIES LIMITED supports customers with comprehensive quality documentation, impurity data and technical assistance to help meet these requirements in different markets.
By sourcing Doramectin 117704-25-3 from TCS GROUP, veterinary pharmaceutical manufacturers gain a trusted macrocyclic lactone API backed by strong process control, technical expertise and an aligned anti-infective and antiparasitic portfolio.