Sodium Starch Glycolate: Superdisintegrant for Rapid Tablet Disintegration
Sodium starch glycolate (SSG) is a cross-linked, carboxymethylated sodium starch derivative that swells rapidly and extensively on contact with water — up to 200–300 times its own volume. This massive swelling generates the disruptive force needed to break apart compressed tablets within seconds to minutes. SSG is one of the three classic superdisintegrants (alongside croscarmellose sodium and crospovidone) and is effective at low concentrations.
Product Profile
| CAS Number | 9063-38-1 |
|---|---|
| Appearance | White to off-white, free-flowing powder |
| Function | Superdisintegrant |
| Typical Use Level | 2–8% (optimum usually 4–6%) |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
SSG is used in both direct compression and wet granulation tablet processes. It is typically added extragranularly at 2–4%, or split between intragranular and extragranular portions for optimal performance. Unlike crospovidone (which acts primarily by wicking), SSG disintegrates primarily by swelling, making it particularly effective in formulations with high drug loading. It is compatible with most APIs and other excipients, though its performance can be reduced by hydrophobic lubricants if over-mixed. In hard gelatin capsule formulations, SSG promotes rapid shell disruption and drug release.
Why Source from TCS
TCS supplies Sodium Starch Glycolate in pharmaceutical grade to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Sodium Starch Glycolate –9063-38-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Sodium Starch Glycolate –9063-38-1 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Sodium Starch Glycolate –9063-38-1?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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