Ergothioneine: Amino Acid Antioxidant for Anti-Pollution and Anti-Aging
Ergothioneine (EGT) is a naturally occurring thiol-histidine betaine amino acid found in mushrooms, particularly Boletus edulis and Pleurotus species. It is actively taken up by human cells via the specific transporter OCTN1 (SLC22A4), concentrating in tissues exposed to high oxidative stress — skin, lens, liver, bone marrow, and erythrocytes. Ergothioneine is a potent scavenger of singlet oxygen, hydroxyl radicals, and hypochlorous acid, with superior stability to glutathione.
Product Profile
| CAS Number | 497-30-3 |
|---|---|
| Molecular Formula | C9H15N3O2S |
| Appearance | White to off-white crystalline powder |
| Function | Antioxidant active / anti-pollution agent |
| Typical Use Level | 0.01–0.1% in skincare formulations |
Applications
In cosmetics, ergothioneine is used as a high-performance antioxidant in anti-pollution and anti-aging formulations. Its selective uptake by keratinocytes and fibroblasts via OCTN1 provides targeted protection at the cellular level, distinguishing it from non-specific antioxidants. EGT protects against UV-induced lipid peroxidation, inhibits melanogenesis (showing potential as a brightening agent), and reduces the inflammatory cascade triggered by urban pollutants including PM2.5 and ozone. It is water-soluble, heat-stable, and compatible with a wide range of cosmetic ingredients. Ergothioneine is also gaining traction as a longevity-associated nutraceutical ingredient.
Why Source from TCS
TCS supplies ergothioneine to cosmetic, nutraceutical, and personal care companies across Europe and globally. Flexible order quantities from formulation development samples to production scale. Contact us with your specifications and volume requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Ergothioneine –497-30-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Ergothioneine –497-30-3 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Ergothioneine –497-30-3?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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