TCS Industries Limited (China-sourced API supplier) supplies Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer CAS 7585-39-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer |
|---|---|
| Structural Formula |  |
| CAS Number | 7585-39-9 |
| Molecular Formula | C42H70O35 |
| Molecular Weight | 1135.0 g/mol |
| InChIKey | WHGYBXFWUBPSRW-FOUAGVGXSA-N |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Beta-Cyclodextrin (CAS 7585-39-9) is a cyclic oligosaccharide composed of seven α(1→4)-linked D-glucopyranose units, with the formula C₄₂H₇₀O₃₅ (MW 1134.98). It has a truncated cone structure with a hydrophobic interior cavity (diameter ~6.0–6.5 Å) and hydrophilic exterior, enabling it to form inclusion complexes with hydrophobic drug molecules. Beta-cyclodextrin is used in pharmaceutical formulations to improve drug solubility, stability, and bioavailability.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Beta-Cyclodextrin in pharmaceutical (USP/Ph.Eur.) and food grades for global procurement programs.
> Applications
Solubility enhancement and drug stabilization
Beta-cyclodextrin forms host-guest inclusion complexes with poorly water-soluble APIs, increasing their apparent aqueous solubility and dissolution rate. The drug molecule enters the hydrophobic cavity while the hydrophilic exterior remains in contact with water. This mechanism is used to formulate BCS Class II (low solubility, high permeability) drugs. Loftsson et al. (J Pharm Sci, 2005, 94:1654–1668) reviewed the role of cyclodextrin complexation in pharmaceutical drug delivery and the factors governing complexation efficiency.
Taste-masking and odor encapsulation
Beta-cyclodextrin encapsulates bitter or unpleasant-tasting drug molecules, reducing sensory perception in oral formulations. In food and industrial applications, it encapsulates flavors, fragrances, and volatile compounds for controlled release and oxidation protection.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples for complexation trials; 25 kg drums for production. Pharmaceutical (USP/Ph.Eur.) and food (E459) grades available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0% beta-cyclodextrin on dried basis), water content (≤14.0%), specific rotation, residue on ignition (≤0.1%), reducing sugars, heavy metals (Pb ≤0.5 ppm), alpha- and gamma-cyclodextrin content (related substances), and microbial limits. White crystalline powder. Meets USP-NF and Ph.Eur. (Betadexum) monographs. COA and MSDS are standard.
> Packaging
Beta-cyclodextrin is a white crystalline powder, slightly hygroscopic. Standard packaging includes 25 kg fibre drums with PE liner. Store at room temperature (15–25 °C) in dry conditions. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Beta-cyclodextrin is monographed in USP-NF (Betadex), Ph.Eur. (Betadexum), and JP. Listed in the FDA IID for oral and topical dosage forms. Approved as a food additive in the EU (E459, maximum use levels apply). GRAS in the US for specific food applications. FDA limits parenteral use due to nephrotoxicity at high systemic doses — modified cyclodextrins (HPBCD, SBECD) are preferred for injectable formulations.
> Alias Index
- IUPAC: Cycloheptaamylose
- CAS Number: 7585-39-9
- Formula: C₄₂H₇₀O₃₅ (MW 1134.98)
- INN: Betadex
- EU food additive: E459
- Pharmacopoeial name: Betadexum (Ph.Eur.)
- Cavity diameter: ~6.0–6.5 Å (suitable for molecules MW 200–800)
- Commercial request terms: beta-cyclodextrin USP, betadex Ph.Eur., E459, drug solubility enhancer, inclusion complex excipient, TCS Industries Limited
> FAQ
What size molecules fit in Beta-Cyclodextrin?
Beta-cyclodextrin has an internal cavity diameter of ~6.0–6.5 Å and a depth of ~7.9 Å. It accommodates guest molecules with molecular weights typically in the 200–800 range, including aromatic rings, steroids, and small heterocycles. Alpha-cyclodextrin (6 glucose, ~4.7 Å) fits smaller guests; gamma-cyclodextrin (8 glucose, ~8.3 Å) fits larger molecules.
What documents are available for Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Why is Beta-Cyclodextrin not used parenterally?
Unmodified beta-cyclodextrin has limited water solubility (~18.5 mg/mL at 25 °C) and causes renal tubular damage at high parenteral doses due to crystallization in renal tubules. Hydroxypropyl-beta-cyclodextrin (HPBCD) and sulfobutylether-beta-cyclodextrin (SBECD, Captisol) are water-soluble derivatives approved for IV administration.
How is an inclusion complex prepared?
Three methods are standard. Co-precipitation: dissolve BCD in water, add drug in solvent, stir, cool, filter. Kneading: mix BCD with drug and minimal water, knead, dry. Spray drying or freeze drying of drug-BCD solutions is used at production scale. The optimal method depends on drug solubility, stability, and scale. Molar ratios are typically 1:1 or 1:2 (drug:BCD).
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Beta-Cyclodextrin –- Inclusion Complex Agent & Solubility Enhancer packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the difference between Beta-Cyclodextrin and HPBCD?
HPBCD (hydroxypropyl-beta-cyclodextrin) is a chemically modified derivative with higher water solubility (>600 mg/mL), no renal toxicity, and suitability for parenteral use. BCD is lower cost and suitable for oral and topical formulations. Both form inclusion complexes with similar guest molecules. Specify the derivative and application at inquiry.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.