Anhydrous Calcium Hydrogen Phosphate (DCPA): Direct Compression Filler
Anhydrous calcium hydrogen phosphate (dibasic calcium phosphate anhydrous, DCPA) is one of the most established inorganic fillers for solid oral dosage forms. Unlike its dihydrate counterpart, the anhydrous form offers excellent flow properties and high compactibility, making it well-suited for direct compression tableting. It also serves as a calcium and phosphorus source in nutritional supplements.
Product Profile
| CAS Number | 7757-93-9 |
|---|---|
| Molecular Formula | CaHPO₄ |
| Appearance | White, free-flowing powder |
| Function | Filler / diluent / calcium source |
| Typical Use Level | 20–50% w/w as tablet filler |
| Compendial Grade | EP / USP-NF |
Formulation Applications
DCPA is widely used as a filler-binder in direct compression formulations where moisture sensitivity is a concern, since it is non-hygroscopic. Formulators frequently combine it with microcrystalline cellulose to balance compactibility and disintegration. Its high density makes it suitable for small-tablet formulations where weight uniformity matters. DCPA is also used as a polishing agent in dentifrices and as a mineral supplement in food and nutritional products. Its chemical inertness makes it compatible with most active ingredients, though it should be used cautiously with tetracycline antibiotics due to potential chelation.
Why Source from TCS
TCS supplies anhydrous calcium hydrogen phosphate in pharmaceutical and food grades to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
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