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Cyclosporin
Cyclosporin A
Cyclosporin A,cas:59865-13-3

Name

Cyclosporin A

CAS

59865-13-3

Synonyms

ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A

MF

C62H111N11O12

MW

1202.61

Others

Ciclosporin (INN/BAN) (pronounced /ˌsaɪkləˈspɔrɪn/);[1] cyclosporine (USAN); cyclosporin (former BAN); or ciclosporin A,[citation needed] cyclosporine A, or cyclosporin A (often shortened to CsA) is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells.[2][3] It was initially isolated from the fungus Tolypocladium inflatum (Beauveria nivea), found in a soil sample obtained in 1969 from Hardangervidda, Norway, by Dr. Hans Peter Frey, a Sandoz biologist.[4] Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.[5]

 

 
 
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