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Vancomycin,cas:1404-90-6
Vancomycin
Vancomycin,cas:1404-90-6

Name

Vancomycin

CAS

1404-90-6

Synonyms

VANCOMYCIN;Vancomycin (base and/or unspecified salts)

MF

C66H75Cl2N9O24

MW

1449.25

Others

Vancomycin INN /væŋkɵˈmaɪsɨn/ is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria. Vancomycin was first isolated in 1953 at Eli Lilly, from a soil sample collected from the interior jungles of Borneo by a missionary. It is a naturally occurring antibiotic made by the soil bacterium Actinobacteria species Amycolatopsis orientalis (formerly designated Nocardia orientalis). It is a complex chemical compound and an example of a comparatively rare haloorganic natural compound, containing two covalently bonded chlorine atoms.

The compound was industrially produced by fermentation and given the generic name vancomycin, derived from the term "vanquish." The original indication for vancomycin was for the treatment of penicillin-resistant Staphylococcus aureus, a use kept alive for many years by the fact that compound had to be given intravenously and thus provided bacteria fewer opportunities to evolve resistance, and the fact that organisms were relatively slow to evolve/adapt to it, even in experiments.

For many years since its initial use, vancomycin had traditionally been reserved as a drug of "last resort" due to early observations of its nephrotoxicity and ototoxicity as well as its intravenous dosing requirements.[1] Recently, however, vancomycin resistant organisms are becoming common. Thus, vancomycin is increasingly being displaced from this role by newer antibiotics such as linezolid (Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).

 

 
 
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